Dr. Tally Largent-Milnes
Principal Investigator | Diagnostic
Tally M. Largent-Milnes, PhD is an Associate Professor in Pharmacology and member of the Comprehensive Center for Pain and Addiction and Bio5 Institute at the University of Arizona. Hearing the Invisible (HTI) is a brainchild of Dr. Largent-Milnes with Professor Stokes to reimaging science communication as art, while advancing applied technologies for early neurological disease interventions. Her role in HTI is the collation of neurological signals of identified disease states, scientific direction, and development of technology applications to promote early detection and intervention of often invisible disease.
Outside of HTI, Dr. Largent-Milnes has worked in the pain field since 2003, trigeminal pain since 2010, and in migraine/headache specifically since 2015. Headache and chronic pain can be comforted with many disorders and headache particularly migraine is a known risk factor for many chronic diseases. Her lab interests meet in the midbrain pain pathways using preclinical models (cortical spreading depression, medication overuse headache) to understand the neurological underpinnings of migraine/headache behaviors during induction and maintenance. Molecular interests in the lab include elucidating the impact of the endocannabinoid signaling and how fluctuations in neurosteroid (e.g. estrogens, progesterone, testosterone) levels play a role in headache pathophysiology. Her trainees include 4 MD/PhD students, 8 PhD students, and more than 50 undergraduate students since 2014. Outside of the lab, Dr. Largent-Milnes enjoys cycling, spending time with her family, reading historical fiction, and finding really good ice cream.